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Berberine Extract

US DMF NO - 038587

A Promising supplement for blood sugar regulation, heart health and more

More info

Berberine Extract

US DMF NO - 038587

Berberine improves glycaemic control, blood lipids, and liver function in metabolic disorders

More info

About Us

Berberine is a quaternary ammonium salt from the protoberberine group of benzylisoquinoline alkaloids found in such plants as Berberis vulgaris / aristata.

People most commonly use berberine for blood sugar control, high levels of cholesterol or other fats in the blood, and for high blood pressure. It supports healthy blood sugar, cholestrol, and triglyceride level.

The Uniqueness of Sunpure’s Berberine

Specifications

  • Product Name : Berberine HCL
  • Scietific Name : Berberis aristata
  • Plant Part Used : Root/Bark
  • Color : A Yellow Crystalline Powder
  • Form : Powder
  • Available Grade : 95% - 99%
  • Method of Analysis : HPLC

How is Berberine Extract different from the rest

  • One of the key differentiating factors of berberine is its ability to impact various aspects of metabolism. It has been studied extensively for its potential to improve Insulin sensitivity, regulate blood sugar levels, lower cholesterol, and support weight loss.
  • Berberine has been the subject of numerous scientific studies investigating its therapeutic potential.
  • Berberine extract has a high diversity of extraction and detection methods due to its physico-chemical properties.

Activities of Berberine HCL

Overcoming One of the Leading Health Issues in the World

  • Blood sugar has become a leading health problem worldwide, affecting millions of people. But there’s good news - berberine, a natural compound, offers a powerful solution to help you manage blood sugar effectively.
  • Inhibition of Gluconeogenesis: Berberine inhibits gluconeogenesis genes, lowering blood sugar levels by decreasing liver glucose production.
  • Stimulation of Glycolysis: Berberine Extracts improve glucose metabolism by stimulating glycolysis and inhibiting mitochondrial oxidation, enhancing glucose utilization.
  • Blood sugar has become a leading health problem worldwide, affecting millions of people. But there’s good news - berberine, a natural compound, offers a powerful solution to help you manage blood sugar effectively.

Who Needs Berberine HCL

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Berberine in Overcoming Blood Sugar Control (Along with Clinical Study)

A study titled “E cacy of berberine in patients with type 2 diabetes mellitus”[1] investigated the efficacy of Berberine and its effects on diabetes and lipid metabolism.

Result

Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo. This study was to determine the efficacy and safety of berberine in the treatment of Type 2 diabetes mellitus patients.

In study A, newly diagnosed Type 2 diabetes mellitus were randomly assigned to treatment with berberine. Significant decreases in haemoglobin A1c, fasting blood glucose, postprandial blood glucose, and plasma triglycerides were observed in the berberine group.

In study B, poorly controlled type 2 diabetes mellitus was treated supplemented with berberine. Berberine acts by lowering fasting blood glucose and postprandial blood glucose. Haemoglobin A1c decreased, fasting plasma insulin and homeostasis model assessment of insulin resistance index was reduced.

In conclusion, this study indicates that berberine is a potent oral hypoglycaemic agent with beneficial effects on diabetes and lipid metabolism.

  • INDIVIDUALS WITH METABOLIC DISORDERS

    • Berberine improves glycaemic control, blood lipids, and liver function in metabolic disorders.

  • INDIVIDUALS WITH HIGH BLOOD SUGAR

    • Berberine has been shown to have powerful blood-sugar-lowering effects and may be as effective as various conventional Type-2 diabetes medications

  • INDIVIDUAL WITH HIGH CHOLESTEROL

    • Berberine has been shown to reduce cholesterol and triglyceride levels while raising HDL (good cholesterol levels)

  • INDIVIDUAL LOOKING FOR NATURAL WEIGHT MANAGEMENT

    • Berberine has been studied for its potential to aid in weight loss by curbing cravings, promoting a feeling of fullness, and supporting healthy metabolism.

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Berberine in Cholesterol Control

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RESULT

  • HFD hamsters exhibited hyperlipidaemic characteristics; Berberine HCL treatment reduced serum TC, TG, and LDL-C levels by 44-70%, 34-51%, and 47-71%, respectively.
  • After Berberine HCL treatment, reductions in liver cholesterol were observed by day 3 and became significant by day 7 at both doses
  • Meanwhile, bile cholesterol was elevated by day 3 and significantly increased at day 10
  • Berberine HCL promoted cholesterol excretion from the liver into the bile in hyperlipidaemic hamsters[3] but not in normal hamsters, and these results provide a link between the cholesterol- lowering effect of Berberine HCL with cholesterol excretion into the bile.

A Natural Pathway

Berberine HCL, as a new medicine for hyperlipidaemia, can reduce the blood lipids in patients. mechanistic studies have shown that Berberine HCL activates the extracellular-signal regulated kinase pathway by stabilizing low- density-lipoprotein receptor mRNA.

Method

Golden hamsters with hyperlipidaemia were fed a high-fat diet for 6 weeks, followed by oral treatment with Berberine HCL or lovastatin. Serum, liver, bile, and faecal cholesterol levels were measured using an enzyme-linked immunosorbent assay.

References

  • Yin, J., Xing, H., & Ye, J. (2008). Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism, 57(5), 712-717.
  • Llyas, Z., Perna, S., Al-Thawadi, S., Alalwan, T. A., Riva, A., Petrangolini, G., ... & Rondanelli, M. (2020). The effect of Berberine on weight loss in order to prevent obesity: A systematic review. Biomedicine & Pharmacotherapy, 127, 110137.
  • Li, X.Y., Zhao, Z. X., Huang, M., Feng, R., He, C. Y., Ma, C., ... & Jiang, J. D. (2015). Effect of Berberine on promoting the excretion of cholesterol in hgh-fat diet-induced hyperlipidemic hamsters. journal of translational medicine, 13(1), 1-9.

Contact Us

Address

Corporate Office :
Sunpure Extacts Private Limited
Sunpure House, Plot No. 11/29, Site-4,
Sahibabad Industrial Area, Ghaziabad,
Uttar Pradesh - 201010, INDIA

Factory :
Sunpure Extracts Private Limited
E-25, Gopalpur Industrial Area, Sikandrabad,
Bulandshahr, Uttar Pradesh - 203205, INDIA

Contact

+91-120-3761106
+91-120-2989896

Email

info@sunpure.co.in

“This statement has not been evaluated by the food and drug administration. This product is not intended to diagnose, treat, cure, or prevent any disease.”